William Stryker

Played by Brian Cox

William Stryker is a military colonel and virulent anti-mutant zealot who ran covert government programs to weaponize and control mutants, including the project that bonded adamantium to Wolverine's skeleton. He orchestrated an assault on Charles Xavier's school and attempted to use Xavier's own telepathic power, magnified through Cerebro, to commit genocide against mutantkind. Read more →

First turns up in X2: X-Men United.