Madame Masque

Whitney Frost, born Agnes Cully, is a brilliant inventor turned Hollywood actress after the scientific establishment refused to take a woman seriously. Exposure to the reality-warping substance Zero Matter grants her extraordinary power at the cost of her sanity, and by the end of Season 2 she's been left insane and committed to an asylum after the substance is torn back out of her.

First turns up in Agent Carter (Season 2).